Description
Benlysta
Buy Benlysta for patients that suffer systemic lupus erythematosus. This medication, with the generic name belimumab, the drug belongs to a group called rheumatologics, and it helps decrease the disease activity compared to when other medicines are used alone.
Who benefits the most from Benlysta
This medication is best used by patients that have SLE and have ongoing kidney problems that are also taking other lupus medication. It is not usually indicated for those who have kidney problems caused by SLE, or have active SLE that also affects the nerves, brain, or spinal cord.
Areas Treated with Benlysta
This solution targets the kidneys, preventing the worsening of kidney function in patients with SLE.
How does Benlysta work?
Benlysta is used mostly on patients with active autoantibody-positive SLE that are already receiving the standard therapy. It can also be prescribed for use on adults that have active lupus nephritis that are already receiving standard therapy. The medication is a sterile, preservative-free, lyophilized powder that is contained in a vial for dilution and reconstitution before intravenous infusion. It binds to the BLyS, or B lymphocyte stimulator, which means that the BLyS can no longer bind to the autoreactive B cells, leading to no stimulation of the said cells. These cells are what produces autoantibodies that attach to normal tissue and attack them.
Treatment Details
Benlysta should be diluted in 0.9% sodium chloride injection, USP with normal saline, 0.45% sodium chloride, USP half-normal saline, or lactated ringer’s injection, USP to a volume of 250ml for intravenous infusion. For patients weighing 40kg or less, 100 ml can be used so that the belimumab concentration inside the bag does not exceed 4mg/ml. From the infusion bag, withdraw and discard volume equal to the reconstituted solution of the medication into the infusion bag or bottle. The bag should then be inverted gently to mix the solution.
For more details, please refer to leaflet or package insert.
How long does Benlysta last?
The reconstituted solution should be stored in a place protected from direct sunlight and refrigerated at a temperature of 2°C to 8°C if not used immediately. The solution is administered via intravenous infusion over a period of 1 hour, and it should not be infused concomitantly in the same intravenous line with other medication.
Safety Information
Patients that have any known allergies or hypersensitivity to any of the components should not use Benlysta. Patients with HIV, a history of hepatitis B or C, a history of major organ transplant or hematopoietic stem cell transplant or renal transplant, or hypogammaglobinemia should avoid this medication.
For a full list of all contraindications and special warnings, please refer to leaflet or package insert.
Other Side Effects
Any sign of allergic reactions should immediately be treated with emergency medical help. Some signs of allergic reactions within hours or days after the injection include:
- Muscle pain
- Tiredness
- Slow heartbeats
- Dizziness
- Itching
- Swelling face or throat
- Nausea
- Trouble breathing
Other common side effects include:
- Diarrhea
- Fever, stuffy nose, and cough
- Pain in arms and legs
- Headache
- Sleep problems
Recovery Time
It can sometimes take up to 8 weeks for a noticeable improvement in symptoms to appear, and four to eight months for the full effects to show. Once these do show, they usually last long-term.
Bottom line
Benlysta has shown some impressive results, with 78% of patients showing marked improvement in the overall symptoms of the disease after 6 months of administration. In 42% of patients, they say the improvement was at least 50%, and researchers also found that Benlysta reduced the risk of worsening kidney function by almost 50%, compared to if patients received standard therapy alone.
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